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 Nutrition  1stholistic.com

Potentially Toxic Dosages and Side Effects of Nutrients

Nutrition Infocenter

Nutrient Toxic Dosage Symptoms and Diseases
Biotin n/a No side effects from oral administration at therapeutic doses have been reported
Boron >10 mg No side effects reported
Calcium >2,000 mg Drowsiness, extreme lethargy, impaired absorption of iron, zinc and manganese, calcium deposits in tissues throughout body, mimicking cancer on X-ray
Carotene >300 mg Orange discoloration of skin, weakness, low blood pressure, weight loss, low white cell count
Chromium >50 mg Dermatitis, intestinal ulcers, kidney and liver impairment
Copper 15 mg Fatigue, poor memory, depression, insomnia, increased production of free radicals, may suppress immune function. Violent vomiting and diarrhea. Cooking acid foods in unlined copper pots can lead to toxic accumulation of copper.
Fluoride, acute 500 mg Poisons several enzymes, (5,000 mg lethal)
Fluoride, chronic 5 mg Fluorosis (white patches on teeth), bone abnormalities.
Folic acid 15 mg Abdominal distention, loss of appetite, nausea, sleep disturbances, may interfere with zinc absorption, may prevent recognition of vitamin B12 deficiency
Iodine 2 mg Thyroid impairment, iodine poisoning or sensitivity reaction.
Iron 25 mg Intestinal upset, interferes with zinc and copper absorption, loss of appetite, not safe for those with iron storage disorders such as hemosiderosis, idiopathic hemochromatosis, or thalassemias. Toxic build-up in liver, pancreas, and heart.
Magnesium N/A Diarrhea at large dosages of poorly absorbed forms (like Epsom salts). Disturbed nervous system function because the calcium-to-magnesium ratio is unbalanced; catharsis, hazard to persons with poor kidney function.
Manganese 75 mg Toxicity only reported in those working in manganese mines or drinking from contaminated water supplies, which results in loss of appetite, neurological damage, loss of memory, hallucinations, hyperirritability, elevation of blood pressure, liver damage. Mask-like facial expression, blurred speech, involuntary laughing, spastic gait, hand tremors.
Niacin (B3), acute 100 mg Transient flushing, headache, cramps, nausea, vomiting
Niacin (B3), chronic 3 gm Anorexia, abnormal glucose tolerance, gastric ulceration, elevated liver enzymes. Excessive uric acid in blood, possibly leading to gout. See Thiamin.
Pantothenic acid (B5) High dose Occasional diarrhea. Increased need for thiamin, possibly causing thiamin deficiency symptoms.
Phosphorous High dose Distortion of calcium-to-phosphorus ratio, creating relative deficiency of calcium.
Potassium High dose Mental impairment, weakness. Excessive potassium in blood, causing muscular paralysis and abnormal heart rhythms.
Pyridoxine (B6) 300 mg Sensory and motor impairment. Dependency on high doses, leading to deficiency symptoms when one returns to normal amounts.
Riboflavin B2) N/A No toxic effects have been noted. See Thiamin.
Selenium 750 micro gm Diabetes, garlic-breath odor, immune impairment, loss of hair and nails, irritability, pallor, skin lesions, tooth decay, nausea, weakness, yellowish skin
Thiamin (B1) N/A No toxic effects noted for humans after oral administration. However, since B Vitamins are interdependent, excess of one may produce deficiency of others.
Vitamin A, acute (infant) 75,000 IU Anorexia, bulging fontanelles, hyperirritability, vomiting
Vitamin A, acute (adult) 2 million IU Headache, drowsiness, nausea, vomiting
Vitamin A, chronic (infant) 10,000 IU Premature epiphyseal bone closing, long bone growth retardation
Vitamin A, chronic (adult) 50,000 IU Anorexia, headache, bluffed vision, loss of hair, bleeding lips, cracking and peeling skin, muscular stiffness and pain, severe liver enlargement and damage, anemia, fetal abnormalities (pregnant women must be very careful), menstrual irregularities, extreme fatigue, liver damage, injury to brain and nervous system.
Vitamin B12 (Cobalamin) N/A No side effects from oral administration have been reported. (See thiamin)
Vitamin C, acute 10 gm Nausea, diarrhea, flatulence
Vitamin C, chronic 3 gm Increased urinary oxalate and uric acid levels in rare cases, impaired carotene utilization, chelation (binding of vitamin C with minerals) and resultant loss of minerals may occur, sudden discontinuation can cause rebound scurvy. Kidney and bladder stones, urinary tract irritation, increased tendency for blood to clot, breakdown of red blood cells in persons with certain common genetic disorders (such as glucose-6-phosphate dehydrogenase deficiency, common in persons of African origin), may induce B12 deficiency.
Vitamin D, acute 70,000 IU Loss of appetite, nausea, vomiting, diarrhea, headache, excessive urination, excessive thirst
Vitamin D, chronic 10,000 IU Weight loss, pallor, constipation, fever, hypocalcaemia. In infants, calcium deposits in kidneys and excessive calcium in blood; in adults, calcium deposits throughout the body (may be mistaken for cancer) (pregnant women must be careful), deafness, nausea, kidney stones, fragile bones, high blood pressure, high blood cholesterol, increased lead absorption.
Vitamin E 1,000 IU The safe dose is probably over 2,000, but some people experience weakness, fatigue, exacerbation of hypertension, increased activity of anticoagulants at 1,000 IU, while some research shows that as little as 300 IU can slow down the immune system. Can destroy some Vitamin K made in the gut. A small amount of immune suppression is probably a reasonable trade off for vitamin E's much needed antioxidant activity.
Vitamin K   No known toxicity with natural (phylloquinone); synthetic (menadione), while relatively safe, when administered to infants may cause hemolytic and liver enlargement. Anemia in laboratory animals.
Zinc 75 mg Gastrointestinal irritation, vomiting, adverse changes in HDL/LDL cholesterol ratios, impaired immunity. Nausea, anemia, bleeding in stomach, premature birth and stillbirth, abdominal pain, fever. Can aggravate marginal copper deficiency. May produce atherosclerosis.

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